Epigenetic regulation of human cancer/testis antigen gene, HAGE, in chronic myeloid leukemia
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چکیده
Original Article Background and Objectives Cancer testis antigens (CTA) provide attractive targets for cancer-specific immunotherapy. Although CTA genes are expressed in some normal tissues, such as the testis, this immunologically protected site lacks MHC I expression and as such, does not present self antigens to T cells. To date, CTA genes have been shown to be expressed in a range of solid tumors via demethylation of their promoter CpG islands, but rarely in chronic myeloid leukemia (CML) or other hematologic malignancies.
منابع مشابه
Retraction: Epigenetic regulation of human cancer/testis antigen gene, HAGE, in chronic myeloid leukemia.
BACKGROUND AND OBJECTIVES Cancer testis antigens (CTA) provide attractive targets for cancer-specific immunotherapy. Although CTA genes are expressed in some normal tissues, such as the testis, this immunologically protected site lacks MHC I expression and as such, does not present self antigens to T cells. To date, CTA genes have been shown to be expressed in a range of solid tumors via demeth...
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تاریخ انتشار 2007